BRD-K10207760_Lasalocid sodium salt_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K10207760_Lasalocid sodium salt_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CALU calumenin
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CDC16 cell division cycle 16
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXL12 F-box and leucine-rich repeat protein 12
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGA fibrinogen alpha chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FOXO3 forkhead box O3
GAS6 growth arrest-specific 6
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GSTA1 glutathione S-transferase alpha 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INHBA inhibin, beta A
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA1033 KIAA1033
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
RAB6A RAB6A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPB surfactant protein B
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
STC2 stanniocalcin 2
STXBP1 syntaxin binding protein 1
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
TMEM41B transmembrane protein 41B
TMEM45A transmembrane protein 45A
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
CALR calreticulin
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP8 GTP-binding protein 8 (putative)
H1FX H1 histone family, member X
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IL1RAP interleukin 1 receptor accessory protein
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KLK8 kallikrein-related peptidase 8
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LHX2 LIM homeobox 2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MTA1 metastasis associated 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP56 NOP56 ribonucleoprotein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCDH7 protocadherin 7
PCNA proliferating cell nuclear antigen
PITX1 paired-like homeodomain 1
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
REG3A regenerating islet-derived 3 alpha
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A4RG SLC2A4 regulator
SNX10 sorting nexin 10
SPDL1 spindle apparatus coiled-coil protein 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
ZBTB10 zinc finger and BTB domain containing 10
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein