BRD-K10207760_Lasalocid sodium salt_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K10207760_Lasalocid sodium salt_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM12 ADAM metallopeptidase domain 12
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
BHLHE40 basic helix-loop-helix family, member e40
CALR calreticulin
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
FADS1 fatty acid desaturase 1
FCGBP Fc fragment of IgG binding protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP6 insulin-like growth factor binding protein 6
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SYBU syntabulin (syntaxin-interacting)
TGIF1 TGFB-induced factor homeobox 1
TPSAB1 tryptase alpha/beta 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AREG amphiregulin
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CAST calpastatin
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
GCH1 GTP cyclohydrolase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HMGN3 high mobility group nucleosomal binding domain 3
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MRPS2 mitochondrial ribosomal protein S2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
PCCB propionyl CoA carboxylase, beta polypeptide
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX9 SRY (sex determining region Y)-box 9
STAP1 signal transducing adaptor family member 1
STK17A serine/threonine kinase 17a
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM165 transmembrane protein 165
TUBB2A tubulin, beta 2A class IIa