BRD-K10207760_Lasalocid sodium salt_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K10207760_Lasalocid sodium salt_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARF4 ADP-ribosylation factor 4
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALU calumenin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDND1 claudin domain containing 1
COL1A1 collagen, type I, alpha 1
COPA coatomer protein complex, subunit alpha
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENO2 enolase 2 (gamma, neuronal)
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OLFM4 olfactomedin 4
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
POU2AF1 POU class 2 associating factor 1
PTPRD protein tyrosine phosphatase, receptor type, D
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC5 serine incorporator 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CD93 CD93 molecule
CDC25A cell division cycle 25A
CENPA centromere protein A
COL3A1 collagen, type III, alpha 1
CTSH cathepsin H
DKK1 dickkopf WNT signaling pathway inhibitor 1
GCH1 GTP cyclohydrolase 1
HIST1H4C histone cluster 1, H4c
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
RGS2 regulator of G-protein signaling 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
STMN1 stathmin 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM5 transmembrane protein 5
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8