BRD-K10207760_Lasalocid sodium salt_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-K10207760_Lasalocid sodium salt_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ALDOC aldolase C, fructose-bisphosphate
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARFIP2 ADP-ribosylation factor interacting protein 2
ARL1 ADP-ribosylation factor-like 1
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKAP4 cytoskeleton-associated protein 4
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COPA coatomer protein complex, subunit alpha
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
COPG1 coatomer protein complex, subunit gamma 1
CREB3L1 cAMP responsive element binding protein 3-like 1
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DHDDS dehydrodolichyl diphosphate synthase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FAM114A1 family with sequence similarity 114, member A1
FAM127A family with sequence similarity 127, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOXO4 forkhead box O4
GOLGA8A golgin A8 family, member A
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFT20 intraflagellar transport 20
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MED8 mediator complex subunit 8
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGM3 phosphoglucomutase 3
POFUT2 protein O-fucosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RABAC1 Rab acceptor 1 (prenylated)
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SEC13 SEC13 homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM39A transmembrane protein 39A
TMEM45A transmembrane protein 45A
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YIPF2 Yip1 domain family, member 2
YIPF3 Yip1 domain family, member 3
YIPF5 Yip1 domain family, member 5
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACACB acetyl-CoA carboxylase beta
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BCHE butyrylcholinesterase
BLM Bloom syndrome, RecQ helicase-like
BST2 bone marrow stromal cell antigen 2
BZW2 basic leucine zipper and W2 domains 2
C1R complement component 1, r subcomponent
C7 complement component 7
CAV2 caveolin 2
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DHFR dihydrofolate reductase
DNA2 DNA replication helicase/nuclease 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EHBP1 EH domain binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP2 epithelial membrane protein 2
EPN2 epsin 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXB7 homeobox B7
HOXC6 homeobox C6
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LYPD1 LY6/PLAUR domain containing 1
MAOB monoamine oxidase B
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MRPS16 mitochondrial ribosomal protein S16
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NFIB nuclear factor I/B
NIT2 nitrilase family, member 2
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
ORC6 origin recognition complex, subunit 6
PALMD palmdelphin
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTMA prothymosin, alpha
PTN pleiotrophin
QDPR quinoid dihydropteridine reductase
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SOBP sine oculis binding protein homolog (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
THBD thrombomodulin
TIMELESS timeless circadian clock
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZWINT ZW10 interacting kinetochore protein