BRD-K10207760_Lasalocid sodium salt_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

277 genes differentially expressed following the BRD-K10207760_Lasalocid sodium salt_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AKAP9 A kinase (PRKA) anchor protein 9
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANXA10 annexin A10
ARF4 ADP-ribosylation factor 4
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CCDC28A coiled-coil domain containing 28A
CCPG1 cell cycle progression 1
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COPA coatomer protein complex, subunit alpha
COPG1 coatomer protein complex, subunit gamma 1
CREB3L1 cAMP responsive element binding protein 3-like 1
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FAM114A1 family with sequence similarity 114, member A1
FAM8A1 family with sequence similarity 8, member A1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GOLGA3 golgin A3
GOLGA8A golgin A8 family, member A
GOLGB1 golgin B1
GOLT1B golgi transport 1B
GPX7 glutathione peroxidase 7
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM3 intercellular adhesion molecule 3
IDI1 isopentenyl-diphosphate delta isomerase 1
IFT20 intraflagellar transport 20
JTB jumping translocation breakpoint
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
KLHDC2 kelch domain containing 2
LIMCH1 LIM and calponin homology domains 1
LONP2 lon peptidase 2, peroxisomal
LOX lysyl oxidase
LZTFL1 leucine zipper transcription factor-like 1
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MLEC malectin
MXI1 MAX interactor 1, dimerization protein
MYDGF myeloid-derived growth factor
NANS N-acetylneuraminic acid synthase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5DC2 5'-nucleotidase domain containing 2
NUCB2 nucleobindin 2
OAT ornithine aminotransferase
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL2 oxysterol binding protein-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PGK1 phosphoglycerate kinase 1
PGM3 phosphoglucomutase 3
PIP prolactin-induced protein
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PROM1 prominin 1
PRRC1 proline-rich coiled-coil 1
PYCR1 pyrroline-5-carboxylate reductase 1
RABAC1 Rab acceptor 1 (prenylated)
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEC13 SEC13 homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SERINC3 serine incorporator 3
SERP1 stress-associated endoplasmic reticulum protein 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPAG4 sperm associated antigen 4
SRPR signal recognition particle receptor (docking protein)
SRPRB signal recognition particle receptor, B subunit
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TCTA T-cell leukemia translocation altered
TM9SF2 transmembrane 9 superfamily member 2
TMEM214 transmembrane protein 214
TMEM243 transmembrane protein 243, mitochondrial
TMEM45A transmembrane protein 45A
TRIM29 tripartite motif containing 29
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YIPF5 Yip1 domain family, member 5
YIPF6 Yip1 domain family, member 6

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
ADA adenosine deaminase
ADGRG1 adhesion G protein-coupled receptor G1
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ARF3 ADP-ribosylation factor 3
AXL AXL receptor tyrosine kinase
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD320 CD320 molecule
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFLAR CASP8 and FADD-like apoptosis regulator
COL4A6 collagen, type IV, alpha 6
CRIP1 cysteine-rich protein 1 (intestinal)
CSK c-src tyrosine kinase
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP2 epithelial membrane protein 2
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT2 fermitin family member 2
FGL2 fibrinogen-like 2
FLNA filamin A, alpha
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KRT81 keratin 81, type II
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LUM lumican
MALL mal, T-cell differentiation protein-like
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MOK MOK protein kinase
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH11 myosin, heavy chain 11, smooth muscle
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NRG1 neuregulin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
TBCB tubulin folding cofactor B
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM164 transmembrane protein 164
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOMM34 translocase of outer mitochondrial membrane 34
TP53I3 tumor protein p53 inducible protein 3
TSPAN4 tetraspanin 4
TTK TTK protein kinase
UPP1 uridine phosphorylase 1
VCL vinculin
WDR1 WD repeat domain 1
ZFP36L1 ZFP36 ring finger protein-like 1