BRD-K09991945_GSK-3 Inhibitor II_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CALD1 caldesmon 1
CD24 CD24 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLIC4 chloride intracellular channel 4
CLU clusterin
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL8A1 collagen, type VIII, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
FBXO11 F-box protein 11
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
ITGA6 integrin, alpha 6
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
LIMCH1 LIM and calponin homology domains 1
LUM lumican
MARS methionyl-tRNA synthetase
MB myoglobin
MGP matrix Gla protein
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RTN2 reticulon 2
SARS seryl-tRNA synthetase
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIX1 SIX homeobox 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARCL1 SPARC-like 1 (hevin)
SPINK4 serine peptidase inhibitor, Kazal type 4
TCTN1 tectonic family member 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNC tenascin C
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADA adenosine deaminase
ADAM12 ADAM metallopeptidase domain 12
BASP1 brain abundant, membrane attached signal protein 1
CHL1 cell adhesion molecule L1-like
CSRP1 cysteine and glycine-rich protein 1
CTSG cathepsin G
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
ELANE elastase, neutrophil expressed
FNBP1 formin binding protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
HAL histidine ammonia-lyase
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
LYPD3 LY6/PLAUR domain containing 3
MFSD10 major facilitator superfamily domain containing 10
MREG melanoregulin
OAT ornithine aminotransferase
RCAN1 regulator of calcineurin 1
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TFPI2 tissue factor pathway inhibitor 2
TIAM1 T-cell lymphoma invasion and metastasis 1