BRD-K09991945_GSK-3 Inhibitor II_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF62 chromosome 6 open reading frame 62
CBS cystathionine-beta-synthase
CCL19 chemokine (C-C motif) ligand 19
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLIC4 chloride intracellular channel 4
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
ELOVL5 ELOVL fatty acid elongase 5
FHL2 four and a half LIM domains 2
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IARS isoleucyl-tRNA synthetase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
LAMP5 lysosomal-associated membrane protein family, member 5
MLPH melanophilin
MT1E metallothionein 1E
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PYCR1 pyrroline-5-carboxylate reductase 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRED2 sprouty-related, EVH1 domain containing 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TARS threonyl-tRNA synthetase
TM9SF3 transmembrane 9 superfamily member 3
TMPRSS3 transmembrane protease, serine 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XYLT1 xylosyltransferase I
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
CADM1 cell adhesion molecule 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC2B C-type lectin domain family 2, member B
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
F13A1 coagulation factor XIII, A1 polypeptide
FST follistatin
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
LYZ lysozyme
NTS neurotensin
PI3 peptidase inhibitor 3, skin-derived
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PTHLH parathyroid hormone-like hormone
RASA4 RAS p21 protein activator 4
RGS2 regulator of G-protein signaling 2
RTN2 reticulon 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase