BRD-K09951645_dabrafenib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-K09951645_dabrafenib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANKMY2 ankyrin repeat and MYND domain containing 2
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BBIP1 BBSome interacting protein 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTN3A2 butyrophilin, subfamily 3, member A2
CALML4 calmodulin-like 4
CAPG capping protein (actin filament), gelsolin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC176 coiled-coil domain containing 176
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CLINT1 clathrin interactor 1
CP ceruloplasmin (ferroxidase)
CREBL2 cAMP responsive element binding protein-like 2
CTSA cathepsin A
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA6 GATA binding protein 6
GCC2 GRIP and coiled-coil domain containing 2
GOLPH3L golgi phosphoprotein 3-like
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRN granulin
GSDMB gasdermin B
GSN gelsolin
H2AFY H2A histone family, member Y
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAC8 placenta-specific 8
PNMA2 paraneoplastic Ma antigen 2
PROM1 prominin 1
PRR15L proline rich 15-like
PRSS8 protease, serine, 8
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RNF114 ring finger protein 114
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
SELENBP1 selenium binding protein 1
SEPHS2 selenophosphate synthetase 2
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SI sucrase-isomaltase (alpha-glucosidase)
SLC22A18 solute carrier family 22, member 18
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SNX2 sorting nexin 2
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SST somatostatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYT17 synaptotagmin XVII
TMC5 transmembrane channel-like 5
TMEM59 transmembrane protein 59
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VIM vimentin
VNN1 vanin 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWA5A von Willebrand factor A domain containing 5A
WDR13 WD repeat domain 13
WDTC1 WD and tetratricopeptide repeats 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AREG amphiregulin
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CD320 CD320 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CHEK1 checkpoint kinase 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSZ cathepsin Z
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL6 ELOVL fatty acid elongase 6
EREG epiregulin
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HK1 hexokinase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IPO5 importin 5
KANK1 KN motif and ankyrin repeat domains 1
KIAA0020 KIAA0020
KIF20A kinesin family member 20A
LCK LCK proto-oncogene, Src family tyrosine kinase
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MINA MYC induced nuclear antigen
MKI67 marker of proliferation Ki-67
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRMT1 protein arginine methyltransferase 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PUS7 pseudouridylate synthase 7 (putative)
RAN RAN, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
SCGB2A2 secretoglobin, family 2A, member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
THBD thrombomodulin
TLR4 toll-like receptor 4
TMEM97 transmembrane protein 97
TNC tenascin C
TRBC1 T cell receptor beta constant 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIP13 thyroid hormone receptor interactor 13
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WDR43 WD repeat domain 43
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)