BRD-K09907482_PRL-3 Inhibitor I_HT29_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AHSG alpha-2-HS-glycoprotein
ATP13A3 ATPase type 13A3
C3 complement component 3
CA12 carbonic anhydrase XII
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CLU clusterin
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
ELOVL6 ELOVL fatty acid elongase 6
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
KYNU kynureninase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MMP11 matrix metallopeptidase 11
MPZL2 myelin protein zero-like 2
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
NEB nebulin
OXSR1 oxidative stress responsive 1
PEX11A peroxisomal biogenesis factor 11 alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALOX5 arachidonate 5-lipoxygenase
ARMCX1 armadillo repeat containing, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNG2 cyclin G2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISP3 cysteine-rich secretory protein 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
IL6ST interleukin 6 signal transducer
IRF7 interferon regulatory factor 7
IRX5 iroquois homeobox 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK11 kallikrein-related peptidase 11
KRT19 keratin 19, type I
MLPH melanophilin
MYLK myosin light chain kinase
NEBL nebulette
NSG1 neuron specific gene family member 1
OLFM1 olfactomedin 1
PAEP progestagen-associated endometrial protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
REG1A regenerating islet-derived 1 alpha
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SOX4 SRY (sex determining region Y)-box 4
TFF3 trefoil factor 3 (intestinal)
TMSB15A thymosin beta 15a
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TYRP1 tyrosinase-related protein 1
WIF1 WNT inhibitory factor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZBTB18 zinc finger and BTB domain containing 18
ZMYND8 zinc finger, MYND-type containing 8