BRD-K09716788_4-chloro-2-(4-isopropylbenzamido)benzoic acid KUC105999N_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K09716788_4-chloro-2-(4-isopropylbenzamido)benzoic acid KUC105999N_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ANXA4 annexin A4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCND2 cyclin D2
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
GAS6 growth arrest-specific 6
HOMER3 homer scaffolding protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MPO myeloperoxidase
NBPF10 neuroblastoma breakpoint family, member 10
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PRR15L proline rich 15-like
RAD21 RAD21 homolog (S. pombe)
RCAN2 regulator of calcineurin 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SMC1A structural maintenance of chromosomes 1A
SPRED2 sprouty-related, EVH1 domain containing 2
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
THBS2 thrombospondin 2
TRIM2 tripartite motif containing 2
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C1S complement component 1, s subcomponent
C21ORF33 chromosome 21 open reading frame 33
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MALL mal, T-cell differentiation protein-like
MARCKSL1 MARCKS-like 1
MIA melanoma inhibitory activity
MRPS16 mitochondrial ribosomal protein S16
MSX1 msh homeobox 1
NCOR2 nuclear receptor corepressor 2
PNMA1 paraneoplastic Ma antigen 1
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
XPO7 exportin 7