BRD-K09549677_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K09549677_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BEX1 brain expressed, X-linked 1
C4BPA complement component 4 binding protein, alpha
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CD36 CD36 molecule (thrombospondin receptor)
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
DDIT4 DNA-damage-inducible transcript 4
ERBB2 erb-b2 receptor tyrosine kinase 2
F5 coagulation factor V (proaccelerin, labile factor)
FADS1 fatty acid desaturase 1
FGG fibrinogen gamma chain
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNMT histamine N-methyltransferase
HOXB6 homeobox B6
HOXC6 homeobox C6
HPN hepsin
KIAA1324 KIAA1324
LEF1 lymphoid enhancer-binding factor 1
LY96 lymphocyte antigen 96
MAGED1 melanoma antigen family D1
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MSX1 msh homeobox 1
MYO10 myosin X
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PLAC8 placenta-specific 8
PLXNC1 plexin C1
RAB38 RAB38, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE4 ribonuclease, RNase A family, 4
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TLR4 toll-like receptor 4
TPD52 tumor protein D52
VAT1 vesicle amine transport 1
VCAN versican

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
CD24 CD24 molecule
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
HACD1 3-hydroxyacyl-CoA dehydratase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
KRT17 keratin 17, type I
KRT19 keratin 19, type I
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
NR4A2 nuclear receptor subfamily 4, group A, member 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLN phospholamban
PNP purine nucleoside phosphorylase
RPL37A ribosomal protein L37a
SAT1 spermidine/spermine N1-acetyltransferase 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
SYNM synemin, intermediate filament protein
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
TMOD1 tropomodulin 1
TRIM29 tripartite motif containing 29
TUBB4B tubulin, beta 4B class IVb
UGCG UDP-glucose ceramide glucosyltransferase
VAMP8 vesicle-associated membrane protein 8