BRD-K09299610_4-(6-methoxynaphthalen-2-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K09299610_4-(6-methoxynaphthalen-2-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
ASGR2 asialoglycoprotein receptor 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLC Charcot-Leyden crystal galectin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
DEFA5 defensin, alpha 5, Paneth cell-specific
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FABP6 fatty acid binding protein 6, ileal
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HBD hemoglobin, delta
HEBP2 heme binding protein 2
HOXB2 homeobox B2
HOXB6 homeobox B6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MSLN mesothelin
NCAPD2 non-SMC condensin I complex, subunit D2
NELL2 NEL-like 2 (chicken)
NFE2 nuclear factor, erythroid 2
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PHF20 PHD finger protein 20
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAI14 retinoic acid induced 14
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM2 tripartite motif containing 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CETN3 centrin, EF-hand protein, 3
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHPT1 choline phosphotransferase 1
CLU clusterin
COCH cochlin
CPM carboxypeptidase M
CRYZ crystallin, zeta (quinone reductase)
DAZAP2 DAZ associated protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
EGR3 early growth response 3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GHR growth hormone receptor
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSTA4 glutathione S-transferase alpha 4
HDGFRP3 hepatoma-derived growth factor, related protein 3
HEBP1 heme binding protein 1
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP1 insulin-like growth factor binding protein 1
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
KRT15 keratin 15, type I
LACTB2 lactamase, beta 2
LYPLA1 lysophospholipase I
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MPZL1 myelin protein zero-like 1
MYO5C myosin VC
NOV nephroblastoma overexpressed
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PFN2 profilin 2
PLTP phospholipid transfer protein
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
REEP5 receptor accessory protein 5
RNF167 ring finger protein 167
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SCEL sciellin
SGCE sarcoglycan, epsilon
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLIT2 slit homolog 2 (Drosophila)
SPEN spen family transcriptional repressor
TBC1D16 TBC1 domain family, member 16
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM100 transmembrane protein 100
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VDAC1 voltage-dependent anion channel 1
XPO7 exportin 7
ZEB2 zinc finger E-box binding homeobox 2
ZNF185 zinc finger protein 185 (LIM domain)