BRD-K08806317_Timolol maleate salt_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-K08806317_Timolol maleate salt_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
C1ORF54 chromosome 1 open reading frame 54
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD86 CD86 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHN1 chimerin 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DPT dermatopontin
EDN3 endothelin 3
EGFL6 EGF-like-domain, multiple 6
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPCAM epithelial cell adhesion molecule
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FKBP4 FK506 binding protein 4, 59kDa
FST follistatin
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGL immunoglobulin lambda locus
IPO13 importin 13
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KIZ kizuna centrosomal protein
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR6 lysophosphatidic acid receptor 6
MANSC1 MANSC domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
NCAPD2 non-SMC condensin I complex, subunit D2
NFE2L3 nuclear factor, erythroid 2-like 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGN osteoglycin
OSBPL10 oxysterol binding protein-like 10
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4A phosphodiesterase 4A, cAMP-specific
PEG10 paternally expressed 10
PLIN2 perilipin 2
PPOX protoporphyrinogen oxidase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
RAB21 RAB21, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TDRD12 tudor domain containing 12
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOA aldolase A, fructose-bisphosphate
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BST2 bone marrow stromal cell antigen 2
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHPT1 choline phosphotransferase 1
COASY CoA synthase
CRISP3 cysteine-rich secretory protein 3
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP10 dual specificity phosphatase 10
EBP emopamil binding protein (sterol isomerase)
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
GAS1 growth arrest-specific 1
GLDC glycine dehydrogenase (decarboxylating)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXC6 homeobox C6
IFITM2 interferon induced transmembrane protein 2
IL6ST interleukin 6 signal transducer
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
KLF2 Kruppel-like factor 2
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LOC399491
LPIN1 lipin 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MARCKS myristoylated alanine-rich protein kinase C substrate
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MTERF3 mitochondrial transcription termination factor 3
NKTR natural killer cell triggering receptor
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PDLIM5 PDZ and LIM domain 5
PHACTR1 phosphatase and actin regulator 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POPDC3 popeye domain containing 3
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
PUF60 poly-U binding splicing factor 60KDa
RCAN1 regulator of calcineurin 1
REEP5 receptor accessory protein 5
SACS sacsin molecular chaperone
SEPT9 septin 9
SORBS3 sorbin and SH3 domain containing 3
SRRM2 serine/arginine repetitive matrix 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRAM1 translocation associated membrane protein 1
TSPAN3 tetraspanin 3