BRD-K08799216_pelitinib_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K08799216_pelitinib_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BST2 bone marrow stromal cell antigen 2
CPA3 carboxypeptidase A3 (mast cell)
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GSTT1 glutathione S-transferase theta 1
H1F0 H1 histone family, member 0
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
KRT18 keratin 18, type I
LEPROT leptin receptor overlapping transcript
NGRN neugrin, neurite outgrowth associated
NKX2-1 NK2 homeobox 1
OXTR oxytocin receptor
PLA2G16 phospholipase A2, group XVI
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SIRT3 sirtuin 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TBC1D31 TBC1 domain family, member 31
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AREG amphiregulin
ATF3 activating transcription factor 3
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CAV2 caveolin 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COG5 component of oligomeric golgi complex 5
COL13A1 collagen, type XIII, alpha 1
COL6A1 collagen, type VI, alpha 1
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DES desmin
DLD dihydrolipoamide dehydrogenase
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
E2F2 E2F transcription factor 2
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFNB2 ephrin-B2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GREM1 gremlin 1, DAN family BMP antagonist
HOXA5 homeobox A5
HOXB2 homeobox B2
IER3 immediate early response 3
JAG1 jagged 1
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLN phospholamban
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAI2 snail family zinc finger 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFRC transferrin receptor
THBD thrombomodulin
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOX3 TOX high mobility group box family member 3