BRD-K08799216_pelitinib_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K08799216_pelitinib_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
C14ORF132 chromosome 14 open reading frame 132
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
MAN1A1 mannosidase, alpha, class 1A, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEX11A peroxisomal biogenesis factor 11 alpha
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PSAT1 phosphoserine aminotransferase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
CCL20 chemokine (C-C motif) ligand 20
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN4 claudin 4
COL15A1 collagen, type XV, alpha 1
CTSS cathepsin S
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EREG epiregulin
EXOSC4 exosome component 4
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBEGF heparin-binding EGF-like growth factor
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HHEX hematopoietically expressed homeobox
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
JUNB jun B proto-oncogene
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT8 keratin 8, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMP22 peripheral myelin protein 22
PTHLH parathyroid hormone-like hormone
RAB38 RAB38, member RAS oncogene family
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
WFDC2 WAP four-disulfide core domain 2