BRD-K08799216_pelitinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K08799216_pelitinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AURKA aurora kinase A
BPI bactericidal/permeability-increasing protein
C5ORF30 chromosome 5 open reading frame 30
CAMP cathelicidin antimicrobial peptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CDC42 cell division cycle 42
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSG cathepsin G
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELANE elastase, neutrophil expressed
FOLR1 folate receptor 1 (adult)
FZD2 frizzled class receptor 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
H2BFS H2B histone family, member S (pseudogene)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI6 interferon, alpha-inducible protein 6
ITGA6 integrin, alpha 6
KDM5A lysine (K)-specific demethylase 5A
LCN2 lipocalin 2
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP8 matrix metallopeptidase 8
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PSAT1 phosphoserine aminotransferase 1
RHOBTB3 Rho-related BTB domain containing 3
S100A12 S100 calcium binding protein A12
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSC22D3 TSC22 domain family, member 3
WNK1 WNK lysine deficient protein kinase 1

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CLU clusterin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INA internexin neuronal intermediate filament protein, alpha
ITGAV integrin, alpha V
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MPZL2 myelin protein zero-like 2
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
MYO10 myosin X
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP4 SH3-domain binding protein 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTSSA serine palmitoyltransferase, small subunit A
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
WFDC2 WAP four-disulfide core domain 2
ZNF512B zinc finger protein 512B