BRD-K08799216_pelitinib_A549_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K08799216_pelitinib_A549_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CARS cysteinyl-tRNA synthetase
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN7 claudin 7
CRIP1 cysteine-rich protein 1 (intestinal)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GARS glycyl-tRNA synthetase
GRB7 growth factor receptor-bound protein 7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
INHBE inhibin, beta E
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LMO4 LIM domain only 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MARS methionyl-tRNA synthetase
MOCOS molybdenum cofactor sulfurase
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL38 ribosomal protein L38
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A14 solute carrier family 39 (zinc transporter), member 14
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
C7 complement component 7
CADM1 cell adhesion molecule 1
CCNA1 cyclin A1
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
FLRT2 fibronectin leucine rich transmembrane protein 2
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KLK11 kallikrein-related peptidase 11
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MYLK myosin light chain kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS2 regulator of G-protein signaling 2
SATB1 SATB homeobox 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TAGLN transgelin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C