BRD-K08799216_pelitinib_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K08799216_pelitinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLGN calmegin
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAS Fas cell surface death receptor
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPR143 G protein-coupled receptor 143
HEPH hephaestin
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER5 immediate early response 5
MSLN mesothelin
NDFIP1 Nedd4 family interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PGF placental growth factor
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
RSAD2 radical S-adenosyl methionine domain containing 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPP1 secreted phosphoprotein 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNE2 cyclin E2
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL9A3 collagen, type IX, alpha 3
DES desmin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
MGP matrix Gla protein
MT1X metallothionein 1X
MYH11 myosin, heavy chain 11, smooth muscle
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PLN phospholamban
POSTN periostin, osteoblast specific factor
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SSBP2 single-stranded DNA binding protein 2
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM2 tropomyosin 2 (beta)
UBE2C ubiquitin-conjugating enzyme E2C
WWTR1 WW domain containing transcription regulator 1