BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMD1 adenosylmethionine decarboxylase 1
CA2 carbonic anhydrase II
COCH cochlin
CREG1 cellular repressor of E1A-stimulated genes 1
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
GJA1 gap junction protein, alpha 1, 43kDa
GUSBP11 glucuronidase, beta pseudogene 11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NKX3-1 NK3 homeobox 1
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
POU2AF1 POU class 2 associating factor 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TKT transketolase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
CCND2 cyclin D2
CD93 CD93 molecule
DHRS2 dehydrogenase/reductase (SDR family) member 2
DOK5 docking protein 5
FOLR1 folate receptor 1 (adult)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SCG5 secretogranin V
SKAP2 src kinase associated phosphoprotein 2
STK10 serine/threonine kinase 10
THBS1 thrombospondin 1
THBS2 thrombospondin 2