BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
BCL2A1 BCL2-related protein A1
CD59 CD59 molecule, complement regulatory protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPCAM epithelial cell adhesion molecule
FOLR1 folate receptor 1 (adult)
GCH1 GTP cyclohydrolase 1
GLUL glutamate-ammonia ligase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
LTF lactotransferrin
MPPED2 metallophosphoesterase domain containing 2
PIP prolactin-induced protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SLA Src-like-adaptor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CBX5 chromobox homolog 5
CEP170 centrosomal protein 170kDa
CTGF connective tissue growth factor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX1 glutathione peroxidase 1
HBB hemoglobin, beta
IFI16 interferon, gamma-inducible protein 16
LACTB2 lactamase, beta 2
LGALS1 lectin, galactoside-binding, soluble, 1
LHFP lipoma HMGIC fusion partner
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MTDH metadherin
NVL nuclear VCP-like
PBX3 pre-B-cell leukemia homeobox 3
PMM2 phosphomannomutase 2
SDC1 syndecan 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON2 spondin 2, extracellular matrix protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D31 TBC1 domain family, member 31
VCAN versican