BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K08640787_3-phenyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AIM2 absent in melanoma 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT1 angiopoietin 1
ANOS1 anosmin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
EFNB2 ephrin-B2
ENO2 enolase 2 (gamma, neuronal)
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LAMA4 laminin, alpha 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP3 nuclear receptor interacting protein 3
NRN1 neuritin 1
NXN nucleoredoxin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
RHOH ras homolog family member H
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX7 sorting nexin 7
SPARCL1 SPARC-like 1 (hevin)
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UBE3B ubiquitin protein ligase E3B
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ASS1 argininosuccinate synthase 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BRCA1 breast cancer 1, early onset
C9ORF3 chromosome 9 open reading frame 3
CAST calpastatin
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DUSP22 dual specificity phosphatase 22
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
FXYD5 FXYD domain containing ion transport regulator 5
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
HBB hemoglobin, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MAP7 microtubule-associated protein 7
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PKP4 plakophilin 4
PLAC8 placenta-specific 8
PSCA prostate stem cell antigen
RAB31 RAB31, member RAS oncogene family
RPS27L ribosomal protein S27-like
S100P S100 calcium binding protein P
SCG5 secretogranin V
SFRP1 secreted frizzled-related protein 1
TFF1 trefoil factor 1
TMEM5 transmembrane protein 5
VCAN versican