BRD-K08589866_OSI-906_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K08589866_OSI-906_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRF5 adhesion G protein-coupled receptor F5
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DIO1 deiodinase, iodothyronine, type I
ENO2 enolase 2 (gamma, neuronal)
FAXDC2 fatty acid hydroxylase domain containing 2
FGG fibrinogen gamma chain
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HHEX hematopoietically expressed homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP5 insulin-like growth factor binding protein 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA8 integrin, alpha 8
JUP junction plakoglobin
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
NCAM1 neural cell adhesion molecule 1
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NKX2-1 NK2 homeobox 1
NRGN neurogranin (protein kinase C substrate, RC3)
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PLIN2 perilipin 2
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PTPRO protein tyrosine phosphatase, receptor type, O
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
SELENBP1 selenium binding protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRA3 adhesion G protein-coupled receptor A3
AKAP7 A kinase (PRKA) anchor protein 7
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
CCNE1 cyclin E1
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CST3 cystatin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFNB2 ephrin-B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLM1 golgi membrane protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IL6R interleukin 6 receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
LDHB lactate dehydrogenase B
LRRC59 leucine rich repeat containing 59
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MECOM MDS1 and EVI1 complex locus
MSX1 msh homeobox 1
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP98 nucleoporin 98kDa
PI3 peptidase inhibitor 3, skin-derived
PRMT1 protein arginine methyltransferase 1
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD23B RAD23 homolog B (S. cerevisiae)
RBMS1 RNA binding motif, single stranded interacting protein 1
RFK riboflavin kinase
SELL selectin L
SET SET nuclear proto-oncogene
SRPX sushi-repeat containing protein, X-linked
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TNC tenascin C
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1