BRD-K08463963_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K08463963_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ANXA1 annexin A1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
CCND2 cyclin D2
CD163 CD163 molecule
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
DSP desmoplakin
DUSP7 dual specificity phosphatase 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
JUP junction plakoglobin
KIAA1551 KIAA1551
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBH limb bud and heart development
LPAR1 lysophosphatidic acid receptor 1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MYOF myoferlin
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRNP prion protein
PTN pleiotrophin
REEP5 receptor accessory protein 5
RHOC ras homolog family member C
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TP63 tumor protein p63
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
UPP1 uridine phosphorylase 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOA2 apolipoprotein A-II
B3GNT1
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
FN1 fibronectin 1
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB14 growth factor receptor-bound protein 14
GYG2 glycogenin 2
ICAM2 intercellular adhesion molecule 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
LBP lipopolysaccharide binding protein
LEFTY1 left-right determination factor 1
MAGED1 melanoma antigen family D1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PCGF2 polycomb group ring finger 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
STIL SCL/TAL1 interrupting locus
TF transferrin
TFRC transferrin receptor
TLR4 toll-like receptor 4
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3