BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

42 genes differentially expressed following the BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANXA1 annexin A1
BHLHE40 basic helix-loop-helix family, member e40
CA2 carbonic anhydrase II
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
KRT14 keratin 14, type I
KRT17 keratin 17, type I
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
THBS1 thrombospondin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BEX1 brain expressed, X-linked 1
CCNE2 cyclin E2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GAS1 growth arrest-specific 1
MSRB2 methionine sulfoxide reductase B2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SELENBP1 selenium binding protein 1
TBC1D16 TBC1 domain family, member 16