BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AXL AXL receptor tyrosine kinase
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLGN calmegin
COL6A2 collagen, type VI, alpha 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPS8 epidermal growth factor receptor pathway substrate 8
FCGBP Fc fragment of IgG binding protein
FGL2 fibrinogen-like 2
FKBP4 FK506 binding protein 4, 59kDa
GLRX glutaredoxin (thioltransferase)
GOLGA8B golgin A8 family, member B
GRB7 growth factor receptor-bound protein 7
HHEX hematopoietically expressed homeobox
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
LINC00341 long intergenic non-protein coding RNA 341
LMO2 LIM domain only 2 (rhombotin-like 1)
MNDA myeloid cell nuclear differentiation antigen
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSX1 msh homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
PRR15L proline rich 15-like
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTCA RNA 3'-terminal phosphate cyclase
RTN1 reticulon 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2B3 SH2B adaptor protein 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SVIL supervillin
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELN elastin
GADD45B growth arrest and DNA-damage-inducible, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MFAP2 microfibrillar-associated protein 2
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
MYLK myosin light chain kinase
NPR3 natriuretic peptide receptor 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RPL37A ribosomal protein L37a
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SKP1 S-phase kinase-associated protein 1
SLC16A4 solute carrier family 16, member 4
SQLE squalene epoxidase
THBS1 thrombospondin 1
TPM1 tropomyosin 1 (alpha)
UGCG UDP-glucose ceramide glucosyltransferase