BRD-K08448573_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K08448573_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG6 adhesion G protein-coupled receptor G6
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
ATF3 activating transcription factor 3
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLCN3 chloride channel, voltage-sensitive 3
CRABP2 cellular retinoic acid binding protein 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM129A family with sequence similarity 129, member A
FAM208B family with sequence similarity 208, member B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGL immunoglobulin lambda locus
IL6ST interleukin 6 signal transducer
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDZD8 PDZ domain containing 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUCO SUN domain containing ossification factor
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM255A transmembrane protein 255A
TSPAN13 tetraspanin 13
USP6NL USP6 N-terminal like
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ANPEP alanyl (membrane) aminopeptidase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCHE butyrylcholinesterase
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
FABP1 fatty acid binding protein 1, liver
FHL1 four and a half LIM domains 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPC3 glypican 3
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFRD2 interferon-related developmental regulator 2
IL17RB interleukin 17 receptor B
KIF20A kinesin family member 20A
LOC100505650 uncharacterized LOC100505650
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
PCP4 Purkinje cell protein 4
PODXL podocalyxin-like
PRKCA protein kinase C, alpha
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PUF60 poly-U binding splicing factor 60KDa
RBP4 retinol binding protein 4, plasma
RTN1 reticulon 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNGR3 synaptogyrin 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa