BRD-K08325710_1-(4-(5-(furan-2-yl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanone KUC105786N_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K08325710_1-(4-(5-(furan-2-yl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanone KUC105786N_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATM ATM serine/threonine kinase
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAG3 BCL2-associated athanogene 3
C1QB complement component 1, q subcomponent, B chain
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP1 cellular retinoic acid binding protein 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM46A family with sequence similarity 46, member A
GUSBP3 glucuronidase, beta pseudogene 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHD immunoglobulin heavy constant delta
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTSS1 metastasis suppressor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PRDX2 peroxiredoxin 2
PTN pleiotrophin
RDX radixin
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SRGN serglycin
STC2 stanniocalcin 2
TPD52L1 tumor protein D52-like 1
TWIST1 twist family bHLH transcription factor 1
VSIG4 V-set and immunoglobulin domain containing 4
XPO7 exportin 7

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
BMP4 bone morphogenetic protein 4
CANT1 calcium activated nucleotidase 1
CERS6 ceramide synthase 6
DMD dystrophin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IRF8 interferon regulatory factor 8
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
MYRF myelin regulatory factor
NFIB nuclear factor I/B
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PALMD palmdelphin
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
REG3A regenerating islet-derived 3 alpha
SDC2 syndecan 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SVIL supervillin
TMEM100 transmembrane protein 100
TSPAN8 tetraspanin 8
VSNL1 visinin-like 1