BRD-K08109215_I-BET_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K08109215_I-BET_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD10 ankyrin repeat domain 10
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C4BPA complement component 4 binding protein, alpha
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CD81 CD81 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CTH cystathionine gamma-lyase
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
G6PD glucose-6-phosphate dehydrogenase
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JARID2 jumonji, AT rich interactive domain 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA1033 KIAA1033
KRT15 keratin 15, type I
LAGE3 L antigen family, member 3
LBH limb bud and heart development
LCN2 lipocalin 2
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MID1 midline 1
MMP10 matrix metallopeptidase 10
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL10 oxysterol binding protein-like 10
OXSR1 oxidative stress responsive 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SNAP25 synaptosomal-associated protein, 25kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSR4 signal sequence receptor, delta
SST somatostatin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSNL1 visinin-like 1
WDTC1 WD and tetratricopeptide repeats 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAA2 acetyl-CoA acyltransferase 2
ACAT1 acetyl-CoA acetyltransferase 1
ACOT9 acyl-CoA thioesterase 9
ADAM12 ADAM metallopeptidase domain 12
ALOX5 arachidonate 5-lipoxygenase
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAALC brain and acute leukemia, cytoplasmic
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD163 CD163 molecule
CDC42 cell division cycle 42
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
CTSS cathepsin S
CXCL14 chemokine (C-X-C motif) ligand 14
CYBB cytochrome b-245, beta polypeptide
CYTIP cytohesin 1 interacting protein
DAXX death-domain associated protein
DRAM1 DNA-damage regulated autophagy modulator 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
F13A1 coagulation factor XIII, A1 polypeptide
FHL1 four and a half LIM domains 1
FLT3 fms-related tyrosine kinase 3
FSD1 fibronectin type III and SPRY domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL13RA2 interleukin 13 receptor, alpha 2
INHBA inhibin, beta A
IRAK3 interleukin-1 receptor-associated kinase 3
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KRT18 keratin 18, type I
LOX lysyl oxidase
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MOK MOK protein kinase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1F metallothionein 1F
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
PCOLCE procollagen C-endopeptidase enhancer
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTH2R parathyroid hormone 2 receptor
PTX3 pentraxin 3, long
PXDN peroxidasin
PYCR1 pyrroline-5-carboxylate reductase 1
RSL1D1 ribosomal L1 domain containing 1
SDC4 syndecan 4
SHCBP1 SHC SH2-domain binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TPBG trophoblast glycoprotein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
VDAC1 voltage-dependent anion channel 1
VSIG4 V-set and immunoglobulin domain containing 4
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91