BRD-K07859598_Raf1 Kinase Inhibitor I_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CXCL9 chemokine (C-X-C motif) ligand 9
ELL2 elongation factor, RNA polymerase II, 2
EXT1 exostosin glycosyltransferase 1
FAM3C family with sequence similarity 3, member C
GADD45A growth arrest and DNA-damage-inducible, alpha
IGL immunoglobulin lambda locus
IL4R interleukin 4 receptor
ITGB6 integrin, beta 6
KANK1 KN motif and ankyrin repeat domains 1
KLHL9 kelch-like family member 9
PCP4 Purkinje cell protein 4
PEA15 phosphoprotein enriched in astrocytes 15
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPAP2B phosphatidic acid phosphatase type 2B
PSG5 pregnancy specific beta-1-glycoprotein 5
RGCC regulator of cell cycle
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SPON2 spondin 2, extracellular matrix protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACB acetyl-CoA carboxylase beta
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
CD93 CD93 molecule
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFHD1 EF-hand domain family, member D1
EMP3 epithelial membrane protein 3
EVL Enah/Vasp-like
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
INSR insulin receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIP prolactin-induced protein
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPS11 ribosomal protein S11
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
TFF1 trefoil factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
ZNF423 zinc finger protein 423
Funding