BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC42 cell division cycle 42
COTL1 coactosin-like F-actin binding protein 1
CST7 cystatin F (leukocystatin)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FCHO1 FCH domain only 1
FOSL1 FOS-like antigen 1
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ITGA6 integrin, alpha 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
NCF4 neutrophil cytosolic factor 4, 40kDa
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
QSOX1 quiescin Q6 sulfhydryl oxidase 1
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BP4 SH3-domain binding protein 4
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
STAP1 signal transducing adaptor family member 1
STC1 stanniocalcin 1
TBXA2R thromboxane A2 receptor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
APOA2 apolipoprotein A-II
APOH apolipoprotein H (beta-2-glycoprotein I)
BAMBI BMP and activin membrane-bound inhibitor
CRABP1 cellular retinoic acid binding protein 1
DAPK1 death-associated protein kinase 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
GTF3A general transcription factor IIIA
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGB1BP1 integrin beta 1 binding protein 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LRRC16A leucine rich repeat containing 16A
MARC1 mitochondrial amidoxime reducing component 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
NGRN neugrin, neurite outgrowth associated
NNMT nicotinamide N-methyltransferase
NTS neurotensin
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
POSTN periostin, osteoblast specific factor
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPIA ribose 5-phosphate isomerase A
RPL37A ribosomal protein L37a
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SMC1A structural maintenance of chromosomes 1A
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
TAGLN transgelin
TF transferrin
THBS4 thrombospondin 4
TPD52L1 tumor protein D52-like 1
VCAN versican
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1