BRD-K07859598_Raf1 Kinase Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CD163 CD163 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDCP1 CUB domain containing protein 1
CFI complement factor I
CKB creatine kinase, brain
CLDN3 claudin 3
CLEC11A C-type lectin domain family 11, member A
COLEC12 collectin sub-family member 12
CSF1R colony stimulating factor 1 receptor
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
DOCK4 dedicator of cytokinesis 4
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
GSTA4 glutathione S-transferase alpha 4
IGFBP4 insulin-like growth factor binding protein 4
KYNU kynureninase
LAMB1 laminin, beta 1
LOC100505650 uncharacterized LOC100505650
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
NAMPT nicotinamide phosphoribosyltransferase
NQO2 NAD(P)H dehydrogenase, quinone 2
NRP1 neuropilin 1
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
WLS wntless Wnt ligand secretion mediator
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
C1ORF106 chromosome 1 open reading frame 106
CLDN10 claudin 10
COMP cartilage oligomeric matrix protein
CREB3L1 cAMP responsive element binding protein 3-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EGF epidermal growth factor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HAPLN1 hyaluronan and proteoglycan link protein 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
KLF2 Kruppel-like factor 2
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LITAF lipopolysaccharide-induced TNF factor
LOX lysyl oxidase
MAGED1 melanoma antigen family D1
NRN1 neuritin 1
PLAC8 placenta-specific 8
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SARAF store-operated calcium entry-associated regulatory factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORBS3 sorbin and SH3 domain containing 3
SPINK1 serine peptidase inhibitor, Kazal type 1
STK26 serine/threonine protein kinase 26
TFRC transferrin receptor
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB18 zinc finger and BTB domain containing 18