BRD-K07691486_roscovitine_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K07691486_roscovitine_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANGPTL4 angiopoietin-like 4
CD1B CD1b molecule
CD1E CD1e molecule
CLCA2 chloride channel accessory 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A5 collagen, type IV, alpha 5
DENND1B DENN/MADD domain containing 1B
DUSP2 dual specificity phosphatase 2
GAGE3 G antigen 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
KIAA0922 KIAA0922
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PALLD palladin, cytoskeletal associated protein
PNMAL1 paraneoplastic Ma antigen family-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RUNX3 runt-related transcription factor 3
SEPT6 septin 6
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM100 transmembrane protein 100
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C2 aldo-keto reductase family 1, member C2
CAST calpastatin
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CKAP4 cytoskeleton-associated protein 4
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP1 cytoplasmic FMR1 interacting protein 1
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HIST1H4C histone cluster 1, H4c
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0101 KIAA0101
LCN2 lipocalin 2
LOX lysyl oxidase
MET MET proto-oncogene, receptor tyrosine kinase
MMP3 matrix metallopeptidase 3
MTUS1 microtubule associated tumor suppressor 1
NPC2 Niemann-Pick disease, type C2
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLS3 plastin 3
PPAP2C phosphatidic acid phosphatase type 2C
PSCA prostate stem cell antigen
RAB13 RAB13, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REXO2 RNA exonuclease 2
RNASE3 ribonuclease, RNase A family, 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRM2 serine/arginine repetitive matrix 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UGCG UDP-glucose ceramide glucosyltransferase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta