BRD-K07691486_roscovitine_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K07691486_roscovitine_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
ENO2 enolase 2 (gamma, neuronal)
EREG epiregulin
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPB8 heat shock 22kDa protein 8
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
NID2 nidogen 2 (osteonidogen)
PAX8 paired box 8
PRUNE2 prune homolog 2 (Drosophila)
S100A7 S100 calcium binding protein A7
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SULF1 sulfatase 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ASPH aspartate beta-hydroxylase
ASPN asporin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CREM cAMP responsive element modulator
FKBP5 FK506 binding protein 5
GNAS GNAS complex locus
GNLY granulysin
HBB hemoglobin, beta
IFITM3 interferon induced transmembrane protein 3
IRS2 insulin receptor substrate 2
KIAA1033 KIAA1033
LUM lumican
MCL1 myeloid cell leukemia 1
OLFM1 olfactomedin 1
PEG10 paternally expressed 10
RGCC regulator of cell cycle
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN13 tetraspanin 13
ZYX zyxin