BRD-K07691486_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K07691486_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AQP1 aquaporin 1 (Colton blood group)
C6ORF48 chromosome 6 open reading frame 48
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGR3 early growth response 3
EPHA2 EPH receptor A2
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
HIST1H2AC histone cluster 1, H2ac
IGFBP7 insulin-like growth factor binding protein 7
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LEF1 lymphoid enhancer-binding factor 1
MCOLN1 mucolipin 1
MICB MHC class I polypeptide-related sequence B
MXRA5 matrix-remodelling associated 5
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
PDIA3 protein disulfide isomerase family A, member 3
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RBP4 retinol binding protein 4, plasma
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SH3YL1 SH3 and SYLF domain containing 1
SNAI2 snail family zinc finger 2
SYNJ2 synaptojanin 2
TAGLN transgelin
THBS1 thrombospondin 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TXNIP thioredoxin interacting protein
VGLL4 vestigial-like family member 4
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AURKB aurora kinase B
CASC3 cancer susceptibility candidate 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FABP1 fatty acid binding protein 1, liver
FCGBP Fc fragment of IgG binding protein
H3F3B H3 histone, family 3B (H3.3B)
HAMP hepcidin antimicrobial peptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
JMJD6 jumonji domain containing 6
KLF2 Kruppel-like factor 2
LOC100505650 uncharacterized LOC100505650
LTBP1 latent transforming growth factor beta binding protein 1
MGLL monoglyceride lipase
NREP neuronal regeneration related protein
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NUP85 nucleoporin 85kDa
PALMD palmdelphin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SGK1 serum/glucocorticoid regulated kinase 1
TCF4 transcription factor 4
TFRC transferrin receptor
TUBA1A tubulin, alpha 1a
TUBB4B tubulin, beta 4B class IVb
WNT5A wingless-type MMTV integration site family, member 5A