BRD-K07667918_linsitinib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K07667918_linsitinib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALOX15B arachidonate 15-lipoxygenase, type B
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2A1 BCL2-related protein A1
BRD4 bromodomain containing 4
CAV1 caveolin 1, caveolae protein, 22kDa
CD52 CD52 molecule
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DAPK1 death-associated protein kinase 1
DUSP2 dual specificity phosphatase 2
FABP4 fatty acid binding protein 4, adipocyte
GAS1 growth arrest-specific 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
IGFBP4 insulin-like growth factor binding protein 4
IL6 interleukin 6
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NARFL nuclear prelamin A recognition factor-like
NR0B1 nuclear receptor subfamily 0, group B, member 1
PI3 peptidase inhibitor 3, skin-derived
POSTN periostin, osteoblast specific factor
PRKCB protein kinase C, beta
PTGES prostaglandin E synthase
RAB31 RAB31, member RAS oncogene family
RAD23A RAD23 homolog A (S. cerevisiae)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ASRGL1 asparaginase like 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CFD complement factor D (adipsin)
CST1 cystatin SN
DSG2 desmoglein 2
EIF4B eukaryotic translation initiation factor 4B
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
FOLR1 folate receptor 1 (adult)
GMPR2 guanosine monophosphate reductase 2
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LYN LYN proto-oncogene, Src family tyrosine kinase
MICB MHC class I polypeptide-related sequence B
MT1E metallothionein 1E
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OXA1L oxidase (cytochrome c) assembly 1-like
PBX3 pre-B-cell leukemia homeobox 3
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEC11A SEC11 homolog A (S. cerevisiae)
VAMP8 vesicle-associated membrane protein 8