BRD-K07667918_linsitinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

45 genes differentially expressed following the BRD-K07667918_linsitinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AREG amphiregulin
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
DDIT4 DNA-damage-inducible transcript 4
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FOXO4 forkhead box O4
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
INHBB inhibin, beta B
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
MFAP2 microfibrillar-associated protein 2
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDFIP1 Nedd4 family interacting protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
SEPP1 selenoprotein P, plasma, 1
SOX11 SRY (sex determining region Y)-box 11
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
WDR45 WD repeat domain 45

decreased expression

Symbol Name
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COL5A2 collagen, type V, alpha 2
CSTA cystatin A (stefin A)
EIF5A eukaryotic translation initiation factor 5A
EPHA3 EPH receptor A3
HSPB8 heat shock 22kDa protein 8
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
LTF lactotransferrin
PCNA proliferating cell nuclear antigen
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS4 regulator of G-protein signaling 4
XIST X inactive specific transcript (non-protein coding)