BRD-K07667918_linsitinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K07667918_linsitinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADH6 alcohol dehydrogenase 6 (class V)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
BCL6 B-cell CLL/lymphoma 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CAST calpastatin
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP1 cysteine-rich protein 1 (intestinal)
CTTN cortactin
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FGB fibrinogen beta chain
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPER1 G protein-coupled estrogen receptor 1
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
HADH hydroxyacyl-CoA dehydrogenase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KYNU kynureninase
MAMLD1 mastermind-like domain containing 1
NOV nephroblastoma overexpressed
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OPTN optineurin
PAH phenylalanine hydroxylase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PFKL phosphofructokinase, liver
PHYH phytanoyl-CoA 2-hydroxylase
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
SORBS3 sorbin and SH3 domain containing 3
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TSKU tsukushi, small leucine rich proteoglycan
TWF2 twinfilin actin binding protein 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD200 CD200 molecule
CD24 CD24 molecule
CHI3L2 chitinase 3-like 2
CHN1 chimerin 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CYB561 cytochrome b561
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FILIP1L filamin A interacting protein 1-like
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGL immunoglobulin lambda locus
LDLR low density lipoprotein receptor
LTF lactotransferrin
LUM lumican
P3H2 prolyl 3-hydroxylase 2
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPC surfactant protein C
SQLE squalene epoxidase
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMPRSS2 transmembrane protease, serine 2
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN5 tetraspanin 5
VIM vimentin