BRD-K07667918_linsitinib_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K07667918_linsitinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ANXA4 annexin A4
APLP2 amyloid beta (A4) precursor-like protein 2
ARMCX2 armadillo repeat containing, X-linked 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR2 early growth response 2
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GSTT1 glutathione S-transferase theta 1
IGFBP6 insulin-like growth factor binding protein 6
KLHL21 kelch-like family member 21
MAOA monoamine oxidase A
NBEA neurobeachin
NMU neuromedin U
OXTR oxytocin receptor
PLTP phospholipid transfer protein
PROM1 prominin 1
PTHLH parathyroid hormone-like hormone
REEP5 receptor accessory protein 5
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
VAT1 vesicle amine transport 1
VWF von Willebrand factor

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA2 carbonic anhydrase II
CD24 CD24 molecule
COL1A1 collagen, type I, alpha 1
CRIP2 cysteine-rich protein 2
CRISP3 cysteine-rich secretory protein 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FKBP14 FK506 binding protein 14, 22 kDa
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
IARS isoleucyl-tRNA synthetase
MSMB microseminoprotein, beta-
MTF2 metal response element binding transcription factor 2
NPY neuropeptide Y
ODC1 ornithine decarboxylase 1
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
THAP11 THAP domain containing 11
TSPAN8 tetraspanin 8