BRD-K07303502_Arachidonyl trifluoro-methyl ketone_RMGI_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_RMGI_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM10 ADAM metallopeptidase domain 10
ADAMDEC1 ADAM-like, decysin 1
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA1 annexin A1
APOC1 apolipoprotein C-I
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CHL1 cell adhesion molecule L1-like
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSTL1 follistatin-like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GMFG glia maturation factor, gamma
GRAMD1C GRAM domain containing 1C
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KYNU kynureninase
LXN latexin
LY96 lymphocyte antigen 96
MBNL2 muscleblind-like splicing regulator 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NKG7 natural killer cell granule protein 7
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PIP prolactin-induced protein
PLSCR4 phospholipid scramblase 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STK10 serine/threonine kinase 10
SULF1 sulfatase 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TRIM36 tripartite motif containing 36
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKB creatine kinase, brain
CRLF1 cytokine receptor-like factor 1
CTSH cathepsin H
DDAH2 dimethylarginine dimethylaminohydrolase 2
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
GNAS GNAS complex locus
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCOLN1 mucolipin 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDE8B phosphodiesterase 8B
PRMT1 protein arginine methyltransferase 1
PRSS8 protease, serine, 8
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
RRBP1 ribosome binding protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SFTPB surfactant protein B
SNN stannin
TACSTD2 tumor-associated calcium signal transducer 2
TESC tescalcin
TFF1 trefoil factor 1