BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MDST8_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MDST8_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ALOX15B arachidonate 15-lipoxygenase, type B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BIN1 bridging integrator 1
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CD300A CD300a molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
CPM carboxypeptidase M
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXPH5 exophilin 5
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FAR2 fatty acyl CoA reductase 2
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FHOD3 formin homology 2 domain containing 3
FMOD fibromodulin
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2C integral membrane protein 2C
JAM3 junctional adhesion molecule 3
KDM5A lysine (K)-specific demethylase 5A
KLHL24 kelch-like family member 24
LIMS1 LIM and senescent cell antigen-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAGE4 P antigen family, member 4 (prostate associated)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PTER phosphotriesterase related
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RET ret proto-oncogene
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPON2 spondin 2, extracellular matrix protein
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STC2 stanniocalcin 2
STXBP6 syntaxin binding protein 6 (amisyn)
TARS threonyl-tRNA synthetase
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TMC5 transmembrane channel-like 5
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52L2 tumor protein D52-like 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
XBP1 X-box binding protein 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AIM2 absent in melanoma 2
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CTPS1 CTP synthase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
HEG1 heart development protein with EGF-like domains 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IL1B interleukin 1, beta
KANK1 KN motif and ankyrin repeat domains 1
KIAA0355 KIAA0355
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LMNB1 lamin B1
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
MSL1 male-specific lethal 1 homolog (Drosophila)
MST1L macrophage stimulating 1-like
MX2 MX dynamin-like GTPase 2
MYCBP MYC binding protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OBSL1 obscurin-like 1
OPHN1 oligophrenin 1
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PLIN1 perilipin 1
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POSTN periostin, osteoblast specific factor
PTTG1 pituitary tumor-transforming 1
RFTN1 raftlin, lipid raft linker 1
RPS26 ribosomal protein S26
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD5 stearoyl-CoA desaturase 5
SOX2 SRY (sex determining region Y)-box 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
UPK1B uroplakin 1B
VSNL1 visinin-like 1
WEE1 WEE1 G2 checkpoint kinase
ZNF512B zinc finger protein 512B