BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HEC108_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HEC108_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C6ORF48 chromosome 6 open reading frame 48
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHMP1B charged multivesicular body protein 1B
CLGN calmegin
CPD carboxypeptidase D
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF5A eukaryotic translation initiation factor 5A
ELOVL2 ELOVL fatty acid elongase 2
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCLM glutamate-cysteine ligase, modifier subunit
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LAMP1 lysosomal-associated membrane protein 1
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBM47 RNA binding motif protein 47
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
STXBP1 syntaxin binding protein 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CA2 carbonic anhydrase II
CD14 CD14 molecule
CLEC5A C-type lectin domain family 5, member A
COL10A1 collagen, type X, alpha 1
COL4A5 collagen, type IV, alpha 5
CXCR4 chemokine (C-X-C motif) receptor 4
HOXA10 homeobox A10
MRPS2 mitochondrial ribosomal protein S2
NCAPD2 non-SMC condensin I complex, subunit D2
PAEP progestagen-associated endometrial protein
PRSS21 protease, serine, 21 (testisin)
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
XIST X inactive specific transcript (non-protein coding)