BRD-K07303502_Arachidonyl trifluoro-methyl ketone_EFO27_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_EFO27_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FGL2 fibrinogen-like 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBP1 HMG-box transcription factor 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IPO13 importin 13
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KDM5A lysine (K)-specific demethylase 5A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MYO6 myosin VI
NQO1 NAD(P)H dehydrogenase, quinone 1
NRGN neurogranin (protein kinase C substrate, RC3)
OSER1 oxidative stress responsive serine-rich 1
PERP PERP, TP53 apoptosis effector
PLBD1 phospholipase B domain containing 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RORA RAR-related orphan receptor A
S100P S100 calcium binding protein P
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG9 sperm associated antigen 9
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STC2 stanniocalcin 2
TBC1D15 TBC1 domain family, member 15
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TOB1 transducer of ERBB2, 1
TOP1 topoisomerase (DNA) I
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBXN7 UBX domain protein 7
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ALCAM activated leukocyte cell adhesion molecule
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CXCL8 chemokine (C-X-C motif) ligand 8
DCT dopachrome tautomerase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAM57A family with sequence similarity 57, member A
GPM6B glycoprotein M6B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
METTL3 methyltransferase like 3
MKI67 marker of proliferation Ki-67
MLANA melan-A
MLEC malectin
MSMB microseminoprotein, beta-
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPH non-SMC condensin I complex, subunit H
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTS neurotensin
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PTX3 pentraxin 3, long
RPS11 ribosomal protein S11
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TNS3 tensin 3
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
TXNL4A thioredoxin-like 4A
WSB2 WD repeat and SOCS box containing 2
ZNF22 zinc finger protein 22