BRD-K07005393_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K07005393_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ANXA1 annexin A1
ARMCX2 armadillo repeat containing, X-linked 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHN2 chimerin 2
COL4A2 collagen, type IV, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FHOD3 formin homology 2 domain containing 3
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GYPC glycophorin C (Gerbich blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IPO13 importin 13
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLHL9 kelch-like family member 9
LOXL1 lysyl oxidase-like 1
LPAR6 lysophosphatidic acid receptor 6
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYOF myoferlin
MZB1 marginal zone B and B1 cell-specific protein
NEFH neurofilament, heavy polypeptide
NLGN4X neuroligin 4, X-linked
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE4B phosphodiesterase 4B, cAMP-specific
PLAU plasminogen activator, urokinase
PTK2 protein tyrosine kinase 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
TIMP2 TIMP metallopeptidase inhibitor 2
TRIM2 tripartite motif containing 2
VLDLR very low density lipoprotein receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
APLP2 amyloid beta (A4) precursor-like protein 2
CHPT1 choline phosphotransferase 1
CLU clusterin
COL2A1 collagen, type II, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
IL1R2 interleukin 1 receptor, type II
KRT10 keratin 10, type I
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTCL1 microtubule crosslinking factor 1
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
PCDH9 protocadherin 9
PLA1A phospholipase A1 member A
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35F2 solute carrier family 35, member F2
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
TP53 tumor protein p53
TRAK1 trafficking protein, kinesin binding 1