BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EFHD1 EF-hand domain family, member D1
ELANE elastase, neutrophil expressed
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GMFG glia maturation factor, gamma
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
LINC00341 long intergenic non-protein coding RNA 341
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MT1M metallothionein 1M
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
STK10 serine/threonine kinase 10
TSPYL2 TSPY-like 2
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACOT9 acyl-CoA thioesterase 9
ACP6 acid phosphatase 6, lysophosphatidic
ACTN1 actinin, alpha 1
AKAP11 A kinase (PRKA) anchor protein 11
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CDC20 cell division cycle 20
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CENPA centromere protein A
COASY CoA synthase
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DPYSL3 dihydropyrimidinase-like 3
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
F2R coagulation factor II (thrombin) receptor
FPGS folylpolyglutamate synthase
FTO fat mass and obesity associated
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GREM1 gremlin 1, DAN family BMP antagonist
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIAA0391 KIAA0391
KLHL9 kelch-like family member 9
KRT1 keratin 1, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY75 lymphocyte antigen 75
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MX2 MX dynamin-like GTPase 2
NAV2 neuron navigator 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NKX3-1 NK3 homeobox 1
NPY neuropeptide Y
PCYOX1L prenylcysteine oxidase 1 like
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RANBP6 RAN binding protein 6
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFXN3 sideroflexin 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMS spermine synthase
SORD sorbitol dehydrogenase
TAPBP TAP binding protein (tapasin)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D16 TBC1 domain family, member 16
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS3 tensin 3
TSC22D1 TSC22 domain family, member 1
TSPYL4 TSPY-like 4
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1