BRD-K06593056_-666_HEPG2_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K06593056_-666_HEPG2_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CEP57 centrosomal protein 57kDa
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IFI16 interferon, gamma-inducible protein 16
MAP1B microtubule-associated protein 1B
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NELL2 NEL-like 2 (chicken)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRDX4 peroxiredoxin 4
RUNX3 runt-related transcription factor 3
TES testin LIM domain protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
CCNB1 cyclin B1
CCNE1 cyclin E1
CDC25B cell division cycle 25B
CENPA centromere protein A
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
NGRN neugrin, neurite outgrowth associated
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
TLR4 toll-like receptor 4
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
UBE2C ubiquitin-conjugating enzyme E2C