BRD-K06569345_HG-5-88-01_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K06569345_HG-5-88-01_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APOE apolipoprotein E
ARL4C ADP-ribosylation factor-like 4C
CALR calreticulin
CRLF1 cytokine receptor-like factor 1
CST3 cystatin C
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
H1F0 H1 histone family, member 0
KAZN kazrin, periplakin interacting protein
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OPN3 opsin 3
PPL periplakin
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CD24 CD24 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DST dystonin
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
GPX2 glutathione peroxidase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXA10 homeobox A10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGA6 integrin, alpha 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PPAP2B phosphatidic acid phosphatase type 2B
SIRT3 sirtuin 3
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3