BRD-K06569345_HG-5-88-01_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K06569345_HG-5-88-01_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CCND2 cyclin D2
CCNG2 cyclin G2
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB2 erb-b2 receptor tyrosine kinase 2
GADD45B growth arrest and DNA-damage-inducible, beta
HES1 hes family bHLH transcription factor 1
HIST3H2A histone cluster 3, H2a
IER5 immediate early response 5
KDM3A lysine (K)-specific demethylase 3A
LCN2 lipocalin 2
LXN latexin
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
PNRC1 proline-rich nuclear receptor coactivator 1
RALGDS ral guanine nucleotide dissociation stimulator
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A12 S100 calcium binding protein A12
SRC SRC proto-oncogene, non-receptor tyrosine kinase
VEGFA vascular endothelial growth factor A
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ANXA5 annexin A5
CCNE2 cyclin E2
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GPM6B glycoprotein M6B
HOXC10 homeobox C10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MLEC malectin
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
SDC2 syndecan 2
SRM spermidine synthase
TUBB2A tubulin, beta 2A class IIa