BRD-K06543683_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K06543683_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD320 CD320 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CERS6 ceramide synthase 6
CFB complement factor B
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL6A3 collagen, type VI, alpha 3
CYBRD1 cytochrome b reductase 1
EID1 EP300 interacting inhibitor of differentiation 1
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLM1 golgi membrane protein 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTRA1 HtrA serine peptidase 1
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LDOC1 leucine zipper, down-regulated in cancer 1
MCUR1 mitochondrial calcium uniporter regulator 1
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
MXRA5 matrix-remodelling associated 5
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PDGFC platelet derived growth factor C
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RAB31 RAB31, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN4 tetraspanin 4
TWIST1 twist family bHLH transcription factor 1
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNE1 cyclin E1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHSY1 chondroitin sulfate synthase 1
CSRP1 cysteine and glycine-rich protein 1
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GCLM glutamate-cysteine ligase, modifier subunit
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA6 integrin, alpha 6
KAT6A K(lysine) acetyltransferase 6A
KIF23 kinesin family member 23
KRT17 keratin 17, type I
KYNU kynureninase
LASP1 LIM and SH3 protein 1
LINC00341 long intergenic non-protein coding RNA 341
LITAF lipopolysaccharide-induced TNF factor
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RAB5C RAB5C, member RAS oncogene family
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SEPHS2 selenophosphate synthetase 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHCBP1 SHC SH2-domain binding protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIK1 salt-inducible kinase 1
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SNRK SNF related kinase
SOX9 SRY (sex determining region Y)-box 9
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK17A serine/threonine kinase 17a
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TMF1 TATA element modulatory factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TUBB3 tubulin, beta 3 class III
TXNRD1 thioredoxin reductase 1
UBAP2L ubiquitin associated protein 2-like
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5