BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BTG1 B-cell translocation gene 1, anti-proliferative
CALML5 calmodulin-like 5
CCDC92 coiled-coil domain containing 92
CD99 CD99 molecule
CLDND1 claudin domain containing 1
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
GLUD2 glutamate dehydrogenase 2
GPX3 glutathione peroxidase 3
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NDRG1 N-myc downstream regulated 1
PDLIM5 PDZ and LIM domain 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
AK1 adenylate kinase 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ASS1 argininosuccinate synthase 1
BAX BCL2-associated X protein
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CTTN cortactin
DHRS2 dehydrogenase/reductase (SDR family) member 2
ETFB electron-transfer-flavoprotein, beta polypeptide
FADD Fas (TNFRSF6)-associated via death domain
GALE UDP-galactose-4-epimerase
IFRD2 interferon-related developmental regulator 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS4 lectin, galactoside-binding, soluble, 4
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOTCH1 notch 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXA1L oxidase (cytochrome c) assembly 1-like
PNKP polynucleotide kinase 3'-phosphatase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TFPI2 tissue factor pathway inhibitor 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)