BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANKHD1 ankyrin repeat and KH domain containing 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD2 CD2 molecule
CD24 CD24 molecule
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CYB561 cytochrome b561
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZR ezrin
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
LTF lactotransferrin
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NKX3-1 NK3 homeobox 1
NUP98 nucleoporin 98kDa
PTGDS prostaglandin D2 synthase 21kDa (brain)
RIPK4 receptor-interacting serine-threonine kinase 4
S100A7 S100 calcium binding protein A7
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D2 TSC22 domain family, member 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANKRD10 ankyrin repeat domain 10
ARMCX2 armadillo repeat containing, X-linked 2
BHLHE41 basic helix-loop-helix family, member e41
BRCA1 breast cancer 1, early onset
CASP6 caspase 6, apoptosis-related cysteine peptidase
DHRS2 dehydrogenase/reductase (SDR family) member 2
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8H golgin A8 family, member H
GSDMB gasdermin B
IFI16 interferon, gamma-inducible protein 16
KRAS Kirsten rat sarcoma viral oncogene homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
NMT1 N-myristoyltransferase 1
PBX1 pre-B-cell leukemia homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PXDN peroxidasin
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI2 tissue factor pathway inhibitor 2
TMEM5 transmembrane protein 5
TPBG trophoblast glycoprotein
VCAN versican